CHE Toxicant and Disease Database
Arrhythmias
Causes [strength of evidence]:
Notes
People with pre-existing coronary artery disease are more susceptible to the ischemic effects of carbon monoxide. Dichloromethane (methylene chloride) and dihalomethanes are metabolized to carbon monoxide in the body. Organic nitrates exposure (mainly in the explosives industry) includes ammonium, sodium nitrate, ethylene glycol dinitrate, nitroglycerin, and TNT and can cause cardiotoxicity in the absence of heart disease. Sudden cardiac death has been reported in glue sniffers.
References:
- Leikin, J.B., et al. Selected Topics Related to Occupational Exposures. Part V. Occupational Cardiovascular Disease. Dis Mon 2000;46(4):311-322.
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