CHE Toxicant and Disease Database
Coronary artery disease, peripheral vascular disease, atherosclerosis
Causes [strength of evidence]:
Notes
Organic nitrates exposure (mainly in the explosives industry) includes ammonium, sodium nitrate, ethylene glycol dinitrate, nitroglycerin, and TNT and can cause cardiotoxicity in the absence of heart disease.
References:
- Bertazzi, P.A. et al. Health Effects of dioxin exposure: a 20-year mortality study. Am J Epidemiol 2001;153(11):1031-1044.
- Brunekeef B, Holgate S. Air pollution and health. Lancet. 2002 Oct 19;360(9341):1233-42.
- Carpenter D.O. et al. Understanding the Human Health Effects of Chemical Mixtures. Environ Health Perspect 2002;110(suppl 1)25-42.
- Guallar, E. et al. Mercury, Fish oils, and the Risk of Myocardial Infarction. N Engl J Med 2002; 347:1747-54.
- Leikin, J.B., et al. Selected Topics Related to Occupational Exposures. Part V. Occupational Cardiovascular Disease. Dis Mon 2000;46(4):311-322.
- Navas-Acien A., Sharrett AR, Silbergeld, EK, et al. Arsenic exposure and cardiovascular disease: a systematic review of the epidemiologic evidence. Am J Epidemiol 162(11): 1037-1049, 2005.
- Yoshizawa, K. et al. Mercury and the Risk of Coronary Heart Disease in Men. New Engl J Med 2002; 347(22):1755-60.
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