CHE Toxicant and Disease Database
Berylliosis
Causes [strength of evidence]:
Notes
Berryliosis is a granulomatous inflammatory disease similar to sarcoidosis, secondary to chronic beryllium exposure. May also involve skin, liver, spleen, salivary glands, kidney, and bone. A genetic predisposition to chronic beryllium disease. has been observed in the MHC II leukocyte antigen marker haplotype, HLA-DPB1, with a glutamic acid residue at position 69.
References:
- McCanlies E.C., et al. HLA-DPB1 and chronic beryllium disease: a HuGE review. Am J Epidemiol 2003; 157(5):388-398.
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