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CHE Toxicant and Disease Database

Altered time to sexual maturation (accelerated or delayed puberty)

Causes [strength of evidence]:

Some chemicals are associated with both delayed and early puberty. For lead, delays in puberty are most marked in African-American and Mexican-American girls with blood lead concentrations 3 mg/dL

  • Aoki, Y. Polychlorinated Biphenyls, Polychlorinated Dibenzo-p-dioxins, and Polychlorinated Dibenzofurans as Endocrine Disrupters - What We Have Learned from Yusho Disease. Environ Res Section A 2001;86:2-11.
  • Baker SR and Wilkinson CF, ed. The Effects of Pesticides on Human Health. Workshop Proceedings, Advances in Modern Environmental Toxicology XVIII. May 9-11, 1998. Princeton Science Publishing, Princeton.
  • Blanck H.M. et al. Age at Menarche and Tanner Stage in Girls Exposed In Utero and Postnatally to Polybrominated Biphenyl. Epidemiol 2000;11:641-647.
  • Bogh, I. B., Christensen, P., Dantzer, V., Groot, M., Thofner, I. C., Rasmussen, R. K., Schmidt, M., & Greve, T. 2001. Endocrine disrupting compounds: effect of octylphenol on reproduction over three generations. Theriogenology, 55(1): 131-150.
  • Den Hond, E., Roels, H., Hoppenbrouwers, K., Nawrot, T., Thijs, L., Vandermeulen, C., Winneke, G., Vanderschueren, D., & Staessen, J. 2002. Sexual maturation in relation to polychlorinated aromatic hydrocarbons: Sharpe and Skakkebaek's hypothesis revisit
  • Denham, M., Schell, L. M., Deane, G., Gallo, M. V., Ravenscroft, J., & DeCaprio, A. P. 2005. Relationship of lead, mercury, mirex, dichlorodiphenyldichloroethylene, hexachlorobenzene, and polychlorinated biphenyls to timing of menarche among Akwesasne Mo
  • Hond E.D., et al. Sexual Maturation in Relation to Polychlorinated Aromatic Hydrocarbons: Sharpe and Skakkebaek's Hypothesis Revisited. Environ Health Perspect 2002;110:771-776.
  • Howdeshell, K. L., Hotchkiss, A. K., Thayer, K. A., Vandenbergh, J. G., & vom Saal, F. S. 1999. Exposure to bisphenol A advances puberty. Nature, 401(6755): 763-764.
  • Laws, S. C., Ferrell, J. M., Stoker, T. E., Schmid, J., & Cooper, R. L. 2000. The effects of atrazine on female wistar rats: an evaluation of the protocol for assessing pubertal development and thyroid function. Toxicol Sci, 58(2): 366-376.
  • Monosson, E., Kelce, W. R., Lambright, C., Ostby, J., & Gray, L. E., Jr. 1999. Peripubertal exposure to the antiandrogenic fungicide, vinclozolin, delays puberty, inhibits the development of androgen-dependent tissues, and alters androgen receptor functi
  • Selevan S.G., et al. Blood Lead Concentration and Delayed Puberty in Girls. NEJM 2003;348(16):1527-1536.
  • Stoker, T., Guidici, D., Laws, S., & Cooper, R. 2002. The effects of atrazine metabolites on puberty and thyroid function in the male Wistar rat. Toxicol Sci, 67(2): 198-206.

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