Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and our methodology.

See also our compilation of other Databases and Resources

For questions or comments about the database, please contact us through our Contact form.

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arsenic

CAS number: 7440-38-2

Diseases linked to this toxicant Grouped by strength of evidence

Strong Evidence Angiosarcoma (hepatic) Arrhythmias Bladder cancer Contact dermatitis - irritant Diabetes - Type II Hearing loss Hyperkeratosis / hyperpigmentation Lung cancer Peripheral neuropathy Skin cancer (non-melanoma) Skin ulceration	Good Evidence Adult-onset leukemias Alopecia (hair loss) Anemia (including hemolytic) Aplastic anemia Bronchitis - chronic Cardiomyopathy Cirrhosis Congenital malformations - general Coronary artery disease, peripheral vascular disease, atherosclerosis Fetotoxicity (miscarriage / spontaneous abortion, stillbirth) Hepatocellular cancer (liver cancer) Hepatoportal sclerosis Hypertension (high blood pressure) Low birth weight / small for gestational age / intra-uterine growth retardation Myocardial infarction (heart attack) Nasal septal perforation Neural tube defects / CNS malformations Pneumonitis (hypersensitivity) Raynaud's phenomenon Renal (kidney) cancer Skeletal malformations Steatosis (fatty liver)	Limited Evidence Acute tubular necrosis Cognitive impairment (includes impaired learning, impaired memory, and decreased attention span) / mental retardation / developmental delay COPD (chronic obstructive pulmonary disease) Genito-urinary malformations (includes male and female) Immune suppression Metal fume fever Myelodysplastic syndrome (pre-leukemia) Neurosthenia (organic affective syndrome) Uterine cancer

NOTE: The toxicant–disease relationships shown above were last updated in 2011. The relationships shown here are still valid, but additional research has been conducted since that time. Additional research on this toxicant can be found at this link:

COMPARATIVE TOXICOGENOMICS DATABASE: CURATED RESULTS

This link will direct your search to an external database, the Comparative Toxicogenomics Database (CTD). This database is different from, and complementary to, our database.

More information about sources and methods

CHE’s Toxicant and Disease Database evaluates existing evidence and categorizes that evidence based on its strength. It is constructed using expert judgment and epidemiological causal inference.
The CTD, in contrast, is a continually updated resource that presents information on a broad range of literature on chemical-disease relationships. It also provides data on genes, biological processes, and phenotypes related to chemicals and diseases. It does not categorize information based on strength of evidence, include an expert judgment process, or draw causal conclusions about toxicant-disease relationships.
The link we have provided on this page goes directly to CTD's curated results, which are a subset of the information available through CTD. Curated results in CTD are those for which studies are available on the toxicant-disease relationship.

References for our 2011 disease list

Carpenter DO, Arcaro K, Spink DC. Understanding the human health effects of chemical mixtures. Environmental Health Perspectives. 2002;110(suppl 1):25-42.

Cohen SM, Shirai T, Steineck G. Epidemiology and etiology of premalignant and malignant urothelial changes. Scandinavian Journal of Urology and Nephrology. Supplementum. 2000; 205:105-115.

Gottschall EB. Occupational and environmental thoracic malignancies. Journal of Thoracic Imaging. 2002 Jul; 17:189-197.

International Agency for Research on Cancer (IARC). Agents Classified by the IARC Monographs. Accessed in 2010.

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Leikin JB, Davis A et al. Selected topics related to occupational exposures. Part IV. Occupational liver disease. Disease-a-Month. 2000 Apr;46(4):296-310.

Leikin JB, Davis A, Klodd DA, Thunder T, Kelafant GA, Paquette DL, Rothe MJ, Rubin R. Selected topics related to occupational exposures. Part V. Occupational cardiovascular disease. Disease-a-Month. 2000 Apr;46(4):311-322.

Longnecker MP, Daniels JL. Environmental contaminants as etiologic factors for diabetes. Environmental Health Perspectives. 2001 Dec;109 Suppl 6:871-6.

Office of Environmental Health Hazard Assessment. Safe Drinking Water and Toxic Enforcement Act of 1986 (California Proposition 65).

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

Dig Deeper

Human environmental disease network: a computational model to assess toxicology of contaminants

About This Database

See a description of database methods, definitions and limitations.

Information in this database was originally drawn from these texts:

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill, 2001.
LaDou J. Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.
Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

Further references are or will be posted with the displays of individual toxicants.