Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and our methodology.

See also our compilation of other Databases and Resources

For questions or comments about the database, please contact us through our Contact form.

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carbon disulfide

CAS number: 75-15-0

Diseases linked to this toxicant Grouped by strength of evidence

Strong Evidence Cognitive impairment (includes impaired learning, impaired memory, and decreased attention span) / mental retardation / developmental delay Coronary artery disease, peripheral vascular disease, atherosclerosis Decreased coordination / dysequilibrium Hearing loss Hypertension (high blood pressure) Myocardial infarction (heart attack) Psychiatric disturbances (disorientation, hallucinations, psychosis, delirium, paranoias, anxiety/depression, emotional lability, mood changes, euphoria) Reduced fertility - male (infertility and subfertility)	Good Evidence Abnormal sperm (morphology, motility, and sperm count) Adult-onset leukemias Arrhythmias Color vision disturbance Decreased vision (includes blindness, retinopathy, optic neuropathy) Dyslipidemia, hypercholesterolemia Erectile dysfunction Fetotoxicity (miscarriage / spontaneous abortion, stillbirth) Lymphoma (non-Hodgkin's) Menstrual disorders (abnormal bleeding, short cycles, long cycles, irregular cycles, painful periods) Parkinson's disease / movement disorders Peripheral neuropathy	Limited Evidence Chronic renal disease Congenital malformations - general Cranio-facial malformations Early onset menopause Glomerulonephritis Hormonal changes (levels of circulating sex hormones - FSH/LH, Inhibin, and/or estrogens, progesterones, androgens, prolactin) Nephrotic syndrome Preterm delivery Thyroid disorders - hypothyroidism

NOTE: The toxicant–disease relationships shown above were last updated in 2011. The relationships shown here are still valid, but additional research has been conducted since that time. Additional research on this toxicant can be found at this link:

COMPARATIVE TOXICOGENOMICS DATABASE: CURATED RESULTS

This link will direct your search to an external database, the Comparative Toxicogenomics Database (CTD). This database is different from, and complementary to, our database.

More information about sources and methods

CHE’s Toxicant and Disease Database evaluates existing evidence and categorizes that evidence based on its strength. It is constructed using expert judgment and epidemiological causal inference.
The CTD, in contrast, is a continually updated resource that presents information on a broad range of literature on chemical-disease relationships. It also provides data on genes, biological processes, and phenotypes related to chemicals and diseases. It does not categorize information based on strength of evidence, include an expert judgment process, or draw causal conclusions about toxicant-disease relationships.
The link we have provided on this page goes directly to CTD's curated results, which are a subset of the information available through CTD. Curated results in CTD are those for which studies are available on the toxicant-disease relationship.

References for our 2011 disease list

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Leikin JB, Davis A, Klodd DA, Thunder T, Kelafant GA, Paquette DL, Rothe MJ, Rubin R. Selected topics related to occupational exposures. Part V. Occupational cardiovascular disease. Disease-a-Month. 2000 Apr;46(4):311-322.

Luo JC, Chang HY, Chang SJ, Chou TC, Chen CJ, Shih TS, Huang CC. Elevated triglyceride and decreased high density lipoprotein level in carbon disulfide workers in Taiwan. Journal of Occupational and Environmental Medicine. 2003 Jan;45(1):73-8.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

Dig Deeper

Human environmental disease network: a computational model to assess toxicology of contaminants

About This Database

See a description of database methods, definitions and limitations.

Information in this database was originally drawn from these texts:

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill, 2001.
LaDou J. Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.
Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

Further references are or will be posted with the displays of individual toxicants.