Toxicant and Disease Database
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The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and our methodology.
See also our compilation of other Databases and Resources
For questions or comments about the database, please contact us through our Contact form.
pesticides
Diseases linked to this toxicant Grouped by strength of evidence
NOTE: The toxicant–disease relationships shown above were last updated in 2011. The relationships shown here are still valid, but additional research has been conducted since that time. Additional research on this toxicant can be found at this link:
COMPARATIVE TOXICOGENOMICS DATABASE: CURATED RESULTS
This link will direct your search to an external database, the Comparative Toxicogenomics Database (CTD). This database is different from, and complementary to, our database.
More information about sources and methods
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CHE’s Toxicant and Disease Database evaluates existing evidence and categorizes that evidence based on its strength. It is constructed using expert judgment and epidemiological causal inference.
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The CTD, in contrast, is a continually updated resource that presents information on a broad range of literature on chemical-disease relationships. It also provides data on genes, biological processes, and phenotypes related to chemicals and diseases. It does not categorize information based on strength of evidence, include an expert judgment process, or draw causal conclusions about toxicant-disease relationships.
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The link we have provided on this page goes directly to CTD's curated results, which are a subset of the information available through CTD. Curated results in CTD are those for which studies are available on the toxicant-disease relationship.
References for our 2011 disease list
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Alavanja MC, Dosemeci M et al. Pesticides and lung cancer risk in the Agricultural Health Study cohort. American Journal of Epidemiology. 2004 Nov 1;160(9):876-85.
Anway MD, Cupp AS, Uzumcu M, Skinner MK. Epigenetic transgenerational actions of endocrine disruptors and male fertility. Science. 2005 Jun 3;308(5727):1466-9.
Arbuckle T, Lin Z, Mery LS. An exploratory analysis of the effect of pesticide exposure on the risk of spontaneous abortion in an Ontario farm population. Environmental Health Perspectives. 2001 Aug;109(8):851-7.
Baker SR, Wilkinson CF, ed. The Effects of Pesticides on Human Health. Workshop Proceedings, Advances in Modern Environmental Toxicology XVIII. May 9-11, 1998. Princeton Science Publishing, Princeton.
Baldi I, Lebailly P, Mohammed-Brahim B, Letenneur L, Dartigues JF, Brochard P. Neurodegenerative diseases and exposure to pesticides in the elderly. American Journal of Epidemiology. 2003; 157(5): 409-414.
Blatter BM, Hermens R, Bakker M, Roeleveld N, Verbeek AL, Zielhuis GA. Paternal occupational exposure around conception and spina bifida in offspring. American Journal of Industrial Medicine. 1997;32:283-291.
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Dich J, Wiklund K. Prostate cancer in pesticide applicators in Swedish agriculture. Prostate. 1998 Feb 1;34(2):100-12.
Dich J, Zahm SH, Hanberg A, Adami HO. Pesticides and cancer. Cancer Causes and Control. 1997 May;8(3):420-43.
Farr SL, Cooper GS, Cai J, Savitz DA, Sandler DP. Pesticide use and menstrual cycle characteristics among premenopausal women in the agricultural health study. American Journal of Epidemiology. 2004 Dec 15;160(12):1194-204.
Figà-Talamanca I, Traina ME, Urbani E. Occupational exposures to metals, solvents, and pesticides: recent evidence on male reproductive effects and biological markers. Occupational Medicine (Oxford, England). 2001 May;51(3):174-88.
Fleming LE, Bean JA, Rudolph M, Hamilton K. Cancer incidence in a cohort of licensed pesticide applicators in Florida. Journal of Occupational and Environmental Medicine. 1999 Apr;41(4):279-88.
Fleming LE, Timmeny W. Aplastic anemia and pesticides: an etiologic association? Journal of Occupational Medicine. 1993 Nov;35(11):1106-16.
Flower KB, Hoppin JA, Lynch CF, Blair A, Knott C, Shore DL, Sandler DP. Cancer risks and parental pesticide application in children of Agricultural Health Study participants. Environmental Health Perspectives. 2004 Apr;112(5):631-635.
Garry VF, Harkins ME, Erickson LL, Long-Simpson LK, Holland SE, Burroughs BL. Birth defects, season of conception, and sex of children born to pesticide applicators living in the Red River Valley of Minnesota, USA. Environmental Health Perspectives. 2002
Garry VF, Holland SE, Erickson LL, Burroughs BL. Male reproductive hormones and thyroid function in pesticide applicators in the Red River Valley of Minnesota. Journal of Toxicology and Environmental Health, Part A. 2003 Jun 13;66(11):965-86.
Greenlee AR, Arbuckle TE, Chyou PH. Risk factors for female infertility in an agricultural region. Epidemiology. 2003; 14(4):429-436.
Holladay SD. Prenatal immunotoxicant exposure and postnatal autoimmune disease. Environmental Health Perspectives. 1999 Oct;107 Suppl 5:687-91.
Holly EA, Aston DA, Ahn DK, Smith AH. Intraocular melanoma linked to occupations and chemical exposures. Epidemiology. 1996 Jan;7(1):55-61.
Hu J, Mao Y, White K. Renal cell carcinoma and occupational exposure to chemicals in Canada. Occupational Medicine (Oxford, England). 2002 May;52(3):157-64.
Ji BT, Silverman DT et al. Occupational exposure to pesticides and pancreatic cancer. American Journal of Industrial Medicine. 2001 Jan;39(1):92-99.
Kauppinen T, Partanen T, Degerth R, Ojajärvi A. Pancreatic cancer and occupational exposures. Epidemiology. 1995 Sep;6(5):498-502.
Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.
LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.
Leikin JB, Davis A et al. Selected topics related to occupational exposures. Part IV. Occupational liver disease. Disease-a-Month. 2000 Apr;46(4):296-310.
Leikin JB, Davis A, Klodd DA, Thunder T, Kelafant GA, Paquette DL, Rothe MJ, Rubin R. Selected topics related to occupational exposures. Part V. Occupational cardiovascular disease. Disease-a-Month. 2000 Apr;46(4):311-322.
Loffredo CA. Epidemiology of cardiovascular malformations: prevalence and risk factors. American Journal of Medical Genetics. 2000 Winter;97(4):319-25.
Ma X, Buffler PA, Gunier RB, Dahl G, Smith MT, Reinier K, Reynolds P. Critical windows of exposure to household pesticides and risk of childhood leukemia. Environmental Health Perspectives. 2002 Sep;110(9):955-960.
Maves MD. Epidemiologic studies of environmental agents and systemic autoimmune diseases. Environmental Health Perspectives. 1999 Oct;107 Suppl 5:743-8.
Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.
Voccia I, Blakley B, Brousseau P, Fournier M. Immnotoxicity of pesticides: a review. Toxicology and Industrial Health. 1999;15:119-132.
