Toxicant and Disease Database
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The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and our methodology.
See also our compilation of other Databases and Resources
For questions or comments about the database, please contact us through our Contact form.
benzene
CAS number: 71-43-2
Diseases linked to this toxicant Grouped by strength of evidence
Strong Evidence Acute non-lymphocytic leukemia | Good Evidence | Limited Evidence Cardiac congenital malformations Hepatocellular cancer (liver cancer) Nasopharyngeal / sino-nasal cancer |
NOTE: The toxicant–disease relationships shown above were last updated in 2011. The relationships shown here are still valid, but additional research has been conducted since that time. Additional research on this toxicant can be found at this link:
COMPARATIVE TOXICOGENOMICS DATABASE: CURATED RESULTS
This link will direct your search to an external database, the Comparative Toxicogenomics Database (CTD). This database is different from, and complementary to, our database.
More information about sources and methods
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CHE’s Toxicant and Disease Database evaluates existing evidence and categorizes that evidence based on its strength. It is constructed using expert judgment and epidemiological causal inference.
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The CTD, in contrast, is a continually updated resource that presents information on a broad range of literature on chemical-disease relationships. It also provides data on genes, biological processes, and phenotypes related to chemicals and diseases. It does not categorize information based on strength of evidence, include an expert judgment process, or draw causal conclusions about toxicant-disease relationships.
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The link we have provided on this page goes directly to CTD's curated results, which are a subset of the information available through CTD. Curated results in CTD are those for which studies are available on the toxicant-disease relationship.
References for our 2011 disease list
DeBruin LS, Josephy PD. Perspectives on the chemical etiology of breast cancer. Environmental Health Perspectives. 2002 Feb;110 Suppl 1:119-28.
Hardell L, Lindström G, van Bavel B, Fredrikson M, Liljegren G. Some aspects of the etiology of non-Hodgkin's lymphoma. Environmental Health Perspectives. 1998 Apr;106(Suppl 2):679-681.
Hu J, Mao Y, White K. Renal cell carcinoma and occupational exposure to chemicals in Canada. Occupational Medicine (Oxford, England). 2002 May;52(3):157-64.
International Agency for Research on Cancer (IARC). Agents Classified by the IARC Monographs. Accessed in 2010.
Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.
Kukull WA, Larson EB et al. Solvent exposure as a risk factor for Alzheimer's disease: a case-control study. American Journal of Epidemiology. 1995 Jun 1;141(11):1059-71; discussion 1072-9.
LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.
Leikin JB, Davis A, Klodd DA, Thunder T, Kelafant GA, Paquette DL, Rothe MJ, Rubin R. Selected topics related to occupational exposures. Part V. Occupational cardiovascular disease. Disease-a-Month. 2000 Apr;46(4):311-322.
Lynge E, Anttila A, Hemminki K. Organic solvents and cancer. Cancer Causes and Control. 1997 May;8(3):406-19.
Maves MD. Epidemiologic studies of environmental agents and systemic autoimmune diseases. Environmental Health Perspectives. 1999 Oct;107 Suppl 5:743-8.
Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.
