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CDC, ATSDR

Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and our methodology.

See also our compilation of other Databases and Resources

For questions or comments about the database, please contact us through our Contact form.

chlorpyrifos

CAS number: 2921-88-2

Diseases linked to this toxicant    Grouped by strength of evidence

Good Evidence

Immune suppression

Low birth weight / small for gestational age / intra-uterine growth retardation

Psychiatric disturbances (disorientation, hallucinations, psychosis, delirium, paranoias, anxiety/depression, emotional lability, mood changes, euphoria)

Limited Evidence

ADD/ADHD, hyperactivity

Autoimmune antibodies (positive ANA, anti-DNA, RF, etc.)

Brain cancer - adult

Cognitive impairment (includes impaired learning, impaired memory, and decreased attention span) / mental retardation / developmental delay

Colorectal cancer

Lung cancer

NOTE: The toxicant–disease relationships  shown above were last updated in 2011. The relationships shown here are still valid, but additional research has been conducted since that time. Additional research on this toxicant can be found at this link:

COMPARATIVE TOXICOGENOMICS DATABASE: CURATED RESULTS

This link will direct your search to an external database, the Comparative Toxicogenomics Database (CTD). This database is different from, and complementary to, our database.

More information about sources and methods

  • CHE’s Toxicant and Disease Database evaluates existing evidence and categorizes that evidence based on its strength. It is constructed using expert judgment and epidemiological causal inference.
  • The CTD, in contrast, is a continually updated resource that presents information on a broad range of literature on chemical-disease relationships. It also provides data on genes, biological processes, and phenotypes related to chemicals and diseases. It does not categorize information based on strength of evidence,  include an expert judgment process, or draw causal conclusions about toxicant-disease relationships.
  • The link we have provided on this page goes directly to CTD's curated results, which are a subset of the information available through CTD. Curated results in CTD are those for which studies are available on the toxicant-disease relationship.

References for our 2011 disease list

Alavanja MC, Dosemeci M et al. Pesticides and lung cancer risk in the Agricultural Health Study cohort. American Journal of Epidemiology. 2004 Nov 1;160(9):876-85.

Flower KB, Hoppin JA, Lynch CF, Blair A, Knott C, Shore DL, Sandler DP. Cancer risks and parental pesticide application in children of Agricultural Health Study participants. Environmental Health Perspectives. 2004 Apr;112(5):631-635.

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Lee WJ, Blair A et al. Cancer Incidence among pesticide applicators exposed to chlorpyrifos in the Agricultural Health Study. Journal of the National Cancer Institute. 2004 Dec 1;96(23):1781-9.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.