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CDC, ATSDR

Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and our methodology.

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Skeletal malformations*

Causes    Grouped by strength of evidence

Strong Evidence

ethyl alcohol (ethanol)

Good Evidence

arsenic

molinate

Limited Evidence

1,1-dichloroethane

atrazine

bromoxynil

chlordecone

ethylene glycol ethers

ethylene oxide

manganese

nicotine

pesticides

Notes

*Includes limb reduction, syndactyly, and polydactyly. Parental exposure to pesticides have been associated with a 3-4 fold risk of skeletal malformations.